منابع مشابه
Malaria vaccine developments.
Large gains in the reduction of malaria mortality in the early 20th century were lost in subsequent decades. Malaria now kills 2-3 million people yearly. Implementation of malaria control technologies such as insecticide-treated bednets and chemotherapy could reduce mortality substantially, but an effective malaria vaccine is also needed. Advances in vaccine technology and immunology are being ...
متن کاملProspects for an AIDS vaccine.
Acquired immunodeficiency syndrome (AIDS) was first identified at the end of 1981.1 In 1983, the causative virus, human immunodeficiency virus (HIV-1), was identified2, almost certainly having entered humans from a reservoir in chimpanzees, possibly on several occasions.3 Since 1981 the virus has spread to cause possibly the most serious epidemic infection in human history. The virus has divers...
متن کاملHIV/AIDS in prisons: recent developments.
In a report released on 20 November 2002, entitled Action on HIV/AIDS in Prisons: Too Little, Too Late--A Report Card, the Canadian HIV/AIDS Legal Network concluded that despite repeated studies and nearly ten years of recommendations for urgent and pragmatic action, the response of Canadian governments to HIV/AIDS, HCV, and injection drug use in prisons remains inadequate. Only a few weeks lat...
متن کاملThe Development of an AIDS Mucosal Vaccine
It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces. Human immunodeficiency virus type one (HIV-1), a mainly sexually transmitted virus, also primar...
متن کاملEngineered Listeria monocytogenes as an AIDS vaccine.
Listeria monocytogenes (Lm) is an attractive vector to elicit T cell immunity because it infects antigen-presenting cells and because infection originates at the mucosa. Lm expressing HIV gag elicits sustained high levels of gag-specific CTL in mice. Since Lm causes disease in immunocompromised hosts, a highly attenuated strain of Lm that requires D-Ala for viability was produced. Attenuated ba...
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ژورنال
عنوان ژورنال: Nature
سال: 1992
ISSN: 0028-0836,1476-4687
DOI: 10.1038/355684b0